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KMID : 0360220180590100908
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Journal of the Korean Ophthalmological Society
2018 Volume.59 No. 10 p.908 ~ p.914
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Long-term Recurrence in Neovascular Age-related Macular Degeneration or Polypoidal Choroidal Vasculopathy without First Year Recurrence
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Tae Kee-Sun
Kim Jong-Woo
Kim Chul-Gu
Lee Dong-Won
Kim Jae-Hui
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Abstract
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Purpose: To investigate the timing and incidence of long-term recurrence in patients with typical neovascular age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV), in patients with no recurrence during the first year after diagnosis.
Methods: A retrospective review of medical records was performed for typical neovascular AMD or PCV patients with no recurrence during 10 months after three, monthly anti-vascular endothelial growth factor injections. The timing and incidence of recurrence after 10 months were identified. In addition, parameters were compared between the recurrence group and the no recurrence group to identify predictive factors for long-term recurrence.
Results: The results were analyzed using 49 eyes from 49 patients, with 19 eyes with typical neovascular AMD and 30 eyes with PCV. Patients were followed-up for a mean period of 32.3 ± 9.3 months after three loading injections. Recurrence was noted in 20 eyes (40.8%) at a mean of 22.6 ± 9.4 months after the third anti-vascular endothelial growth factor injection. The timing of recurrence was as follows: 13 eyes at ≥ 12 months and < 24 months, four eyes at ≥ 24 months and < 36 months, and three eyes at ≥ 36 months. When comparing the recurrence and no-recurrence groups, the follow-up period was significantly longer in the recurrence group (p = 0.003). However, there was no other factors that were significantly associated with recurrence.
Conclusions: Long-term recurrence occurred in 40.8% of the cases when there was no recurrence during the first year after diagnosis. No factors predictive of recurrence were found. These results imply the importance of long-term and continuous follow-up examination of all patients.
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KEYWORD
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Age-related macular degeneration, Anti-vascular endothelial growth factor, Polypoidal choroidal vasculopathy, Recurrence
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